Dare to Challenge Obesity

Obesity Worsens Colon Cancer in Women

April 16, 2009

Obesity Worsens Colon Cancer in Women

Obese Women Fare Worse After Colon Cancer Diagnosis

WebMD Health News

June 30, 2003 -- Obesity not only increases the risk of developing colon cancer, but for women it may also make the disease more dangerous and deadly. New research shows obese women with colon cancer are more likely to die from their disease.

The study, published in the journal Cancer, showed that women with a body mass index (BMI, a measure of weight in relation to height, used to indicate obesity) of more than 30 were 34% more likely to die from their colon cancer than normal-weight women.

But obesity doesn't seem to have the same effect on men's colon cancer. Researchers found men's BMI did not significantly influence survival or cancer recurrence.

Although obesity is a known risk factor for colon cancer, researchers say less is known about the effect of weight on treatment or overall outcomes of people with colon cancer. In the study, researchers followed some 3,800 men and women with advanced (stage II or III) colon cancer.

Among women, researchers found the risk of death due to colon cancer rose as BMI levels increased.

On the positive side, the study also found that obese women had lower rates of chemotherapy-related complications or side effects, such as nausea or vomiting, than normal weight women. Researchers say this is important because it shows that obese women can tolerate chemotherapy at least as well as nonobese patients, even when they are given higher doses because of more body weight.

Although some have suggested that the higher death rates among obese women might reflect the fact that chemotherapy doses are sometimes calculated according to ideal weight rather than actual weight among obese women, the study showed that obese women still fared worse even after adjusting for possible underdosing.

Instead, researcher Jeffrey Meyerhardt, MD, MPH, of the Dana-Farber Cancer Institute, and colleagues say several other factors might explain the gender disparity in the risks faced by obese women with colon cancer.

For example, obese women have higher levels of estrogen circulating in the body, are more likely to be insulin resistant (a precursor to diabetes), and have higher rates of diabetes. All of these factors are thought to promote the growth of cancerous tumors.

Researchers say more studies are needed to confirm this influence of obesity on colon cancer risk, as well as examine the effect of weight loss, physical activity, and diet on the long-term outcome of people with advanced colon cancers.

SOURCE: Cancer, August 1, 2003.


Abdominal Obesity May Be Associated With Colon Cancer Risk

April 10, 2009
Abdominal Obesity May Be Associated With Colon Cancer Risk
Abdominal Obesity May Be Associated With Colon Cancer Risk

Abdominal Obesity May Be Associated With Colon Cancer Risk
06 Jul 2006

Waist circumference and a person's waist-to-hip ratio were linked to an increased risk of colon cancer, a new study suggests.

Tobias Pischon, M.D., of the German Institute of Human Nutrition in Potsdam, and colleagues examined the link between abdominal obesity and colon and rectal cancer in 368,277 subjects from the European Prospective Investigation into Cancer and Nutrition. The subjects were followed for an average of 6.1 years.

The authors identified 984 patients with colon cancer and 586 patients with rectal cancer. A large waist, high waist-to-hip ratio, and height were associated with an increased risk of colon cancer in both men and women. In men, high weight and body mass index were also associated with increased risk of colon cancer.

Contact: Gisela Olias, olias@mail.dife.de

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oxfordjournals.org/.


Highlights in the July 5 JNCI

Contact: Ariel Whitworth
Journal of the National Cancer Institute
Obesity associated with Colon Cancer risk

Strong Link Between Obesity And Colorectal Cancer

April 10, 2009

Strong Link Between Obesity And Colorectal Cancer

ScienceDaily (Dec. 18, 2007) — A clear, direct link between obesity and colorectal cancer, the second most common form of cancer in Australia with more than 12,000 new cases each year, has been shown in a new analysis by The George Institute for International Health in Sydney, Australia.

The report shows that obese individuals (Body Mass Index* (BMI) >30 kg/m2) have a 20% greater risk of developing colorectal cancer compared with those of normal weight (BMI < 25 kg/m2). The analyses also indicated that obese men are at 30% greater risk of developing the cancer compared with obese women. Findings from the study also showed that carrying even a few excess kilos substantially increases the risk of colorectal cancer; for every 5 kg weight gain the risk of developing the cancer increases by 7%.

Dr Rachel Huxley and co-authors at The George Institute reviewed over 70,000 patients in an analysis that included studies all across the globe: "Approximately, one in twenty Australians will develop colorectal cancer in their lifetime and our data clearly indicate that the risk of developing the cancer can be substantially reduced by maintaining a healthy weight" said Dr Huxley.

The new report carries links with the latest report from the World Cancer Research Fund Report, which provides further support regarding the link between obesity and cancer. Importantly, the primary recommendation of the report is; "Be as lean as possible within the normal range of body weight", supported by a public health goal of 'Median adult body mass index (BMI) to be between 21 and 23'. All eight recommendations made in the report were focused on healthy eating, drinking and physical activity, creating a sincere message of the relationship between diet and cancer risk. "Although the mechanisms that explain the link between excess weight and cancer remain to be elucidated, substantial evidence supports an important role for diet and physical activity" added Dr Huxley.

Both the international and George Institute report stress the increasing levels of obesity in both high income and developing countries. "Currently, around 300 million people across the world are obese. This figure is expected to rise up toward 700 million by 2015. Considering that obesity increases the threat of colorectal cancer by 20%, this means that 10,000 cases each year are due to severe excess weight. The number of cases of colorectal cancer alone, caused by obesity, is likely rise to at least 25,000 by 2015," added Dr Huxley.

BMI definition Body Mass Index (BMI) is measured by dividing your body weight in kilograms by height in meters squared. An individual's BMI is associated with their body fat and health risk, a high BMI is >30kg/m2 and normal BMI is 25kg/m2."

The authors conclude by stating, while 20% is a considerable risk, previous reviews have suggested that obesity may be associated with up to 30 -- 60% greater risk of colorectal cancer. However, according to Dr Huxley, "this over-estimation is most likely due to the impact of publication bias in medical and scientific journals. Regardless, a 20% greater risk is still considerable and sends a clear message about watching what you eat and being more physically active."

This research was published December 14 in the journal Cancer Epidemiology, Biomarkers and Prevention.

*The BMI equation is = body weight in kilograms/height in meters squared.


Welcome to Health Watch

February 5, 2009

A lot of the health-related problems encountered by modern man are brought about by the lifestyle he chooses to live. That is why even though man's body and his bodily functions haven't changed for the last couple of thousand years or so, numerous diseases have been constantly evolving and causing ill-health to mankind.

Primitive man's diet used to be simple but modern man's food intake is packed with a lot of unhealthy components - refined sugar, white flour, processed foods filled with antibiotics, hormones and preservatives. Inside our bodies, oxidized fats, cholesterol, free radicals and other such irritating components from the food we consume inflict harm to our bodily systems. No wonder colon cancer is now the second leading cause of cancer deaths in the US!

To restore our health to the most desirable state attainable, we need to eliminate the toxins which have accumulated in our bodies through the food we eat, the medications we take and the environmental pollutants we are exposed to. We need to undergo a major cleansing regimen and it should start with the cleansing of the colon (bowel).

Why start with colon cleansing? The reason behind this is simple. Most diseases originate from a toxic bowel, which develops when the food materials we have consumed stay in our bowels for prolonged periods of time. The longer the food stays inside our system, the more putrefied it will be and the more toxins it will produce. These toxins will eventually be released into the bloodstream and distributed throughout the body.

Imagine how many toxins will be produced when our bowels are constipated? If you move your bowels at least once per day, approximately three meals worth of food will be sitting in your digestive system at any given time! A variety of health-related problems may be in the offing if you are unable to have at least one bowel movement per day. Disease-causing viruses just love to thrive in these conditions!

As nature intended it to be, all the contents of the colon should be expelled regularly to maintain the optimal functioning of the body. However, due to the complex and unhealthy diet of an average person coupled with the unavoidable stress present in everyday life, most Americans develop several layers of toughened mucoid plaque in their colons. This can trigger the weakening of the body's natural defenses against disease-causing organisms since mucoid plaque generally weakens the body.

This is why colon detoxification is very important. Attempts at detoxifying other bodily organs will be futile if the colon is not given precedence. Why? Primarily because if your colon is congested and you attempt to detoxify say your liver or your lymphatic system, the toxins excreted from these organs will only get recycled into your body.

A good bowel cleanse comprises fasting (on water, fruit juices, raw fruits and vegetables), psyllium husk and/or seeds (or flax seeds), bentonite clay, salt water enema and probiotics.

It is essential that you take in a lot of fresh fruits and vegetables, fresh fruit juices and water during the cleansing process to facilitate the regular and easy elimination of putrefying food in your colon. This will greatly decrease the chances of the survival of disease-causing organisms in the body and will enhance the digestion and utilization of nutrients in the foods.

Psyllium husk and/or seeds and flax seeds absorb water and expand in the colon to facilitate the elimination of toxins and excess mucus. Bentonite clay (a form of edible clay) acts in very much the same way. It is also necessary to include probiotics in the regimen to protect the population of friendly bacteria in the intestines.

Michael Russell Your Independent guide to Detoxification

Michael Russell - EzineArticles Expert Author
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